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The Tufts Center for the Study of Drug Development conducts research on a broad range of topics in the areas of drug development, regulation, and utilization. Current research projects are grouped as follows:
Cancer Drugs and Vaccines: Pipelines and Probabilities of Success
Reichert JM (in progress)
Despite advances in treatment options, cancer remains a difficult foe due to the complex nature of the diseases. Pharmaceutical and biotechnology firms have dedicated resources over decades in the quest to develop new drugs and vaccines for cancer. The pipelines of cancer–targeting agents developed by the pharmaceutical and biotechnology industries during 1990 through 2005 will be examined. Drug candidates will be classified by composition of matter (e.g., small molecule, protein therapeutic, monoclonal antibody). Clinical phase transition probabilities and overall approval success rates will be determined for the different candidate types. In addition, clinical development and approval times will be calculated for FDA–approved products. Since few cancer vaccines have undergone FDA review, analysis of vaccine candidates will focus on targets.
These findings will provide a critical assessment of the development of this important class of products.
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